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Tocris/Xanomeline oxalate/3569/10/10 mg
Description:FunctionallyselectiveM1agoNIST
ChemicalName:3-[4-(Hexyloxy)-1,2,5-thiADIazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

FunctionallyselectivemuscarinicM1receptoragonist(EC50valuesare0.3,5,42,52and92.5nMatM1,M3,M5,M4andM2receptorsrespectively).Displaysacomplexpharmacologicalprofile:reversIBLeandwash-resistantbinding,resultinginfullagonistactivityatM1;delayedwash-resistantpartialagonistactivityatM2;anddelayedwash-resistantfullagonistactivityatM4.Exhibitsantipsychoticactivity,andimprovescognitivedeficitsandbehavioraldisturbancesinAlzheimer'sdiseaseandschizophrenia.

CompoundLibraries

XanomelineoxalateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt371.46
FormulaC14H23N3OS.C2H2O4
StorageDesiccateat+4°C
Purity≥98%(HPLC)
CASNumber141064-23-5
PubChemID18920248
InChIKeyZJOUESNWCLASJP-UHFFFAOYSA-N
SmilesCCCCCCOC1=NSN=C1C2=CCCN(C)C2.OC(C(O)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO37.15100
ethanol9.2925
water3.7110mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight371.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.69mL13.46mL26.92mL
5mM0.54mL2.69mL5.38mL
10mM0.27mL1.35mL2.69mL
50mM0.05mL0.27mL0.54mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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