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GPR35agonist.InducesGPR35internalizationandactivatesERK1/2(EC50valuesare22and65nMrespectively).Mediatesrecruitmentofβ-arrestin2toGPR35.Alsoexhibitsantinociceptiveeffectsinamousemodelofvisceralpain.
| M.Wt | 432.33 |
| Formula | C23H14Na2O6 |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 6640-22-8 |
| PubChemID | 2723841 |
| InChIKey | YGLLICRFEVEWOZ-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].OC1=C(CC2=C3C=CC=CC3=CC(C([O-])=O)=C2O)C2=CC=CC=C2C=C1C([O-])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.42 | 75 | |
| water | 43.23 | 100 |
Thefollowingdataisbasedontheproductmolecularweight432.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.31mL | 11.57mL | 23.13mL |
| 5mM | 0.46mL | 2.31mL | 4.63mL |
| 10mM | 0.23mL | 1.16mL | 2.31mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |