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Tocris/LY 2389575 hydrochloride/4969/50/50 mg
Description:SelectivenegativeallostericmodulatorofmGlu3
ChemicalName:(3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-aminehydrochloride
Purity:≥98%(HPLC)
BiologicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectivenegativeallostericmodulatorofmGlu3(IC50=190nM).Exhibits>65-foldselectivityformGlu3overothermGlureceptors.AbolishestheneuroprotectiveactionofLY379268againstamyloidβtoxicityinmixedcorticalneuronalandastrocytecellcultures.

TechnicalData

M.Wt438.58
FormulaC15H15BrCl2N4.HCl
StorageDesiccateatRT
Purity≥98%(HPLC)
CASNumber885104-09-6
PubChemID11503054
InChIKeyIRIBLLOEUZMCQY-ZOWNYOTGSA-N
SmilesClC1=CC(Cl)=CC=C1CN[C@@H]2CN(C3=NC=C(Br)C=N3)CC2.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO8.7720

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight438.58.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.28mL11.4mL22.8mL
5mM0.46mL2.28mL4.56mL
10mM0.23mL1.14mL2.28mL
50mM0.05mL0.23mL0.46mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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