SB 612111 hydrochloride Supplier | CAS 371980948 | SB612111 hydrochloride | Tocris Bioscience

化学名：7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride纯度：97%(HPLC)
生物活性

SelectiveNOPreceptorantagonist(Kivaluesare0.33,57.6,160.5and2109nMforNOP,-,-and-receptorsrespectively).Antagonizesthepronociceptiveactionofnociceptin(Cat.No.0910)inanacutepainmodel.Potentiatestheactionofmorphineinmorphine-tolerantanimalsandblockshyperalgesiainaninflammatorypainmodel.

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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以下数据基于产品分子量454.86。Batchspecificmolecularweightsmayvaryfrombatchtobatchduetothedegreeofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
MolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.

*Whenpreparingstocksolutionsalwaysusethebatch-specificmolecularweightoftheproductfoundontheviallabelandSDS/CoA(availableonline).

Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.

etal(2004)Modificationofnociceptionandmor.tolerancebytheselectiveopiatereceptor-likeorphanreceptorantagonist(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol(SB-612111)J.Pharmacol.Exp.Ther.308454PMID:14593080

Rizzietal(2007)Pharmacologicalcharacterizationofthenociceptin/orphaninFQreceptorantagonistSB-612111[(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]:invivostudies.J.Pharmacol.Exp.Ther.321968PMID:17329551

Spagnoloetal(2007)Pharmacologicalcharacterizationofthenociceptin/orphaninFQreceptorantagonistSB-612111[(-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]:invitrostudies.J.Pharm.Exp.Ther.106961

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关键词:SB612111hydrochloride,SB612111hydrochloridesupplier,SB612111,hydrochloride,opioids,NOP,receptors,antagonists,ORL1,N/OFQ,Receptors,3573,TocrisBioscience

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