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Tocris/Zamifenacin fumarate/2579/10/10 mg
Description:SelectiveM3antagonist
AlternativeNames:UK76654
ChemicalName:(3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidinefumarate
Purity:≥99%(HPLC)
BiologicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveM3muscarinicreceptorantagonist(pKivaluesare8.52,7.93,7.90and7.78forM3,M2,M1andM4receptorsrespectively).DisplayshigheraffinityatilealM3receptors(pKi=9.3)comparedtooesophagealandtrachealM3receptors(pKivaluesare8.8and8.2respectively).Inhibitsgastrointestinalmotilityinvivointheabsenceofcardiovasculareffects.

CompoundLibraries

ZamifenacinfumarateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt531.6
FormulaC27H29NO3.C4H4O4
StorageDesiccateat+4°C
Purity≥99%(HPLC)
CASNumber127308-98-9
PubChemID20056967
InChIKeyPMHKTAIGYOVZEZ-ZHWJIHCSSA-N
SmilesC1(CCN3C[C@H](OC(C5=CC=CC=C5)C4=CC=CC=C4)CCC3)=CC=C(OCO2)C2=C1.C(C=CC(O[H])=O)(O[H])=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO53.16100
ethanol13.2925

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight531.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.88mL9.41mL18.81mL
5mM0.38mL1.88mL3.76mL
10mM0.19mL0.94mL1.88mL
50mM0.04mL0.19mL0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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