化学名：N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide纯度：98%(HPLC)
生物活性
InhibitorofWntprocessingandsecretion.InactivatesPORCN,amembrane-boundO-acyltransferase(MBOAT),andselectivelyinhibitspalmitoylationofWnt.BlocksWnt-dependentphosphorylationofLrp6receptorandDvl2,and-cateninaccumulation.Suppressesself-renewalinR1embryonicstemcellsandpromotescardiomyocytedifferentiationfromhPSCs.
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
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以下数据基于产品分子量466.6。Batchspecificmolecularweightsmayvaryfrombatchtobatchduetothedegreeofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
MolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.
*Whenpreparingstocksolutionsalwaysusethebatch-specificmolecularweightoftheproductfoundontheviallabelandSDS/CoA(availableonline).
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
关键词:IWP2,IWP2supplier,MBOAT,membrane-bound,o-acyltransferases,Porcupine,porcn,wnt,secretion,production,signaling,signalling,inhibitors,inhibits,inactivators,inactivates,IWP2,beta-catenin,-catenin,b-catenin,stem,cell,proliferation,Stem,Cell,Signaling,Proliferation,PORCN,Organoids,Cardiomyocyte,Cells,3533,TocrisBioscience
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IuseitasablockingmoleculeoftheWNTpathwayforcardiacdifferentiationinforeskinfibroblast-deriveIPScells.Iobtainedsuccesfullycardiomyocytesina5uMconcentration.
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OurGMPstemcellcompoundsaresuitableforuseasancillaryreagents(rawmaterials)forthefurthermanufacturingofstemcelltherapies.
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Cat.No.6775O-GlcNActransferase(OGT)inhibitor
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