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Tocris/Piperlongumine/4396/50/50 mg
Description:Inducesapoptosis;increasesp53andROSlevelsincancercells
ChemicalName:5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone
Purity:≥97%(HPLC)
BiologicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inducescelldeathandincreasesthelevelofreactiveoxygenspecies(ROS)incancercellswithbothwild-typeandnormalp53.Alsoinhibitsthegrowthofspontaneousmalignantbreasttumorsinmice.Displayslittleeffectonnormalcells.RapidlydepletesandrogenreceptorexpressioninhumanprostatecancercellsviaaROS-dependent,proteasome-mediatedmechanism.

TechnicalData

M.Wt317.34
FormulaC17H19NO5
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber20069-09-4
PubChemID637858
InChIKeyVABYUUZNAVQNPG-BQYQJAHWSA-N
SmilesO=C1N(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO31.73100
ethanol6.3520mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight317.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.15mL15.76mL31.51mL
5mM0.63mL3.15mL6.3mL
10mM0.32mL1.58mL3.15mL
50mM0.06mL0.32mL0.63mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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