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PositiveallostericmodulatorofmuscarinicM1receptors(EC50=198nM).DisplaysnoactivityatM2-M5atconcentrationsupto30μM.PotentiatesNMDAreceptorcurrentsinhippocampalneurons;activityreversescognitivedecifitsinarodentmodelofhippocampal-dependentmemory.CNSpenetrant.
| M.Wt | 369.89 |
| Formula | C18H27N3O3.HCl |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1135242-13-5 |
| PubChemID | 25010775 |
| InChIKey | XKJQVUIXSBOCPP-UHFFFAOYSA-N |
| Smiles | CC1=CC=CC=C1C(NCCNC2CCN(C(OCC)=O)CC2)=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 1.85 | 5 | |
| water | 9.25 | 25 |
Thefollowingdataisbasedontheproductmolecularweight369.89.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.7mL | 13.52mL | 27.04mL |
| 5mM | 0.54mL | 2.7mL | 5.41mL |
| 10mM | 0.27mL | 1.35mL | 2.7mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |