PotentandselectivecompetitiveleukotrieneD4andE4receptorantagonist.InhibitsLTD4-butnothistamine-inducedguineapigileumandtracheacontraction(pA2=8.7).AlsoinhibitsLTD4-attenuationofhumanPMNchemotaxis.Orallyactiveinvivo.
SR2640hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 406.87 |
| Formula | C23H18N2O3.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 146662-42-2 |
| PubChemID | 45073453 |
| InChIKey | KDSYWFCTUKABKE-UHFFFAOYSA-N |
| Smiles | Cl.OC(=O)C1=CC=CC=C1NC1=CC(OCC2=CC=C3C=CC=CC3=N2)=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.34 | 50 |
Thefollowingdataisbasedontheproductmolecularweight406.87.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.46mL | 12.29mL | 24.58mL |
| 5mM | 0.49mL | 2.46mL | 4.92mL |
| 10mM | 0.25mL | 1.23mL | 2.46mL |
| 50mM | 0.05mL | 0.25mL | 0.49mL |