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Tocris/Cinnabarinic acid/4119/50/50 mg
Description:SelectivemGlu4agonist
ChemicalName:2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylicacid
Purity:≥98%(HPLC)
BiologicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

mGlu4receptoragonist.ActivatesmGlu4receptorsintransientlytransfectedHEK293cells;selectiveoverallothermGlusubtypes(mGlu1,mGlu2andmGlu5-8).DecreasescAMPlevelsinnativeculturedcerebellargranulecells.AlsocounteractsexcitotoxicneuronalcelldeathinducedbyNMDAinmixedculturesofcorticalcells;displaysneuroprotectiveactivity.

TechnicalData

M.Wt300.22
FormulaC14H8N2O6
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber606-59-7
PubChemID114918
InChIKeyFSBKJYLVDRVPTK-UHFFFAOYSA-N
SmilesO=C2C(N)=C(C(O)=O)C1=NC3=C(C=CC=C3C(O)=O)OC1=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO30.02100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight300.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.33mL16.65mL33.31mL
5mM0.67mL3.33mL6.66mL
10mM0.33mL1.67mL3.33mL
50mM0.07mL0.33mL0.67mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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