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Selective inducer of neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs). Selectively suppresses astrocyte differentiation when induced by LIF, BMP2 and FBS compared to retinoic acid. Enhances maturation of NPC derived neurons.
Neuropathiazol is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
| M. Wt | 338.42 |
| Formula | C19H18N2O2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 880090-88-0 |
| PubChem ID | 11667240 |
| InChI Key | MGKYEWWFHSESJN-UHFFFAOYSA-N |
| Smiles | O=C(OCC)C1=CC=C(N(C2=CSC(C3=CC=CC=C3)=N2)C)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.84 | 100 | |
| ethanol | 6.77 | 20 |
The following data is based on the product molecular weight 338.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.77 mL | 29.55 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.91 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
References are publications that support the products' biological activity.
Warashina et al (2006) A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew Chem. Int. Ed. Engl. 45 591 PMID: 16323231
Keywords: Neuropathiazol, supplier, Selective, inducers, neuronal, differentiation, neural, progenitor, cells, NPCs, stem, cells, Neural, Stem, Cells, Neural, Stem, Cells, Tocris Bioscience