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The most abundant peptide neurotransmitter in the mammalian CNS. A weak activator of NMDA receptors, and a highly selective agonist for mGlu3 receptors. Neuroprotective under non-hydrolysing conditions in vivo.
| M. Wt | 304.26 |
| Formula | C11H16N2O8 |
| Storage | Store at -20°C |
| Purity | ≥96% (HPLC) |
| CAS Number | 3106-85-2 |
| PubChem ID | 188803 |
| InChI Key | OPVPGKGADVGKTG-BQBZGAKWSA-N |
| Smiles | CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.43 | 100 |
The following data is based on the product molecular weight 304.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.29 mL | 16.43 mL | 32.87 mL |
| 5 mM | 0.66 mL | 3.29 mL | 6.57 mL |
| 10 mM | 0.33 mL | 1.64 mL | 3.29 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
References are publications that support the products' biological activity.
Neale et al (2000) N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J.Neurochem. 75 443 PMID: 10899918
Thomas et al (2000) N-Acetylated α-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin. J.Pharmacol.Exp.Ther. 295 16 PMID: 10991955
Wroblewska et al (1997) N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J.Neurochem. 69 174 PMID: 9202308
Keywords: Spaglumic acid, supplier, Putative, endogenous, neurotransmitter, Selective, mGlu3, agonists, Glutamate, mGlur, Receptors, Metabotropic, Group, II, iGluR, Ionotropic, alpha-NAAG, NAAG, a-NAAG, Glutamate, (Metabotropic), Group, II, Receptors, Miscellaneous, Glutamate, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience