企业QQ
官方微信
SelectiveCCR1receptorantagonist(Kivaluesare0.04,>10,>10and>10nMforCCR1,CCR5,CXCR2andCXCR4receptorsrespectively).InhibitsMIP-1α-inducedintracellularcalciummobilization(IC50=2.5μM).AlsoafullinverseagonistatUS28,a HCMV-encodedchemokinereceptor.
| M.Wt | 481.46 |
| Formula | C28H29ClN2O.HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1216540-18-9 |
| PubChemID | 56972186 |
| InChIKey | SSZWNUGWOGONQJ-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C2(O)CCN(CCCC(C4=CC=CC=C4)(C#N)C3=CC=CC=C3)CC2)C=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.15 | 100 | |
| ethanol | 24.07 | 50 |
Thefollowingdataisbasedontheproductmolecularweight481.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.08mL | 10.39mL | 20.77mL |
| 5mM | 0.42mL | 2.08mL | 4.15mL |
| 10mM | 0.21mL | 1.04mL | 2.08mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |