IBL/17-OH-Progesterone ELISA/RE52071/

17-OH-progesterone(17-OHP)isthemostsuitablebiochemicalMarkerforthediagnosisofcongenitaladrenalhyperplasia(CAH).CAHhasaprevalenceof1-20in10,000childrenanditisoneofthemostfrequentinbornendocrinedisorders.

ThemostcommonformofCAHisduetoadeficiencyoftheenzyme21-hydroxylase.Dependingontheseverityoftheenzymaticdefect,theCAHrelatedsymptomsvaryfromsaltlostsyndromeininfantstohirsutismand/orinfertilitythatmanifestduringpubertyoradulthood(late-onsetCAH).

AdvantagesoftheIBLInternational17-OHPELISA

• Excellentanalyticalcharacteristics
• Forthe17-OHPserumELISAage-dependentreferencerangesforchildren
• Easy17-OHPmonitoringinsaliva
• Serum,plasmaELISA:EU:CE
• Easytoadapttoautomatedinstruments

Measuring17-OHPenablesearlydiagnosisandtreatmentofpatientssufferingfromCAH.

Femalepatientswithlate-onsetCAHusuallyhave17-OHPconcentrationsabovethereferenceintervalduringthefollicularphaseofthemenstrualcycle.

17-OHPissecretedinabundantexcessinaffectedinfantswith21-hydroxylasedeficiencywhencomparedtohealthychildren.Normalserum17-OHPvaluesininfantsandchildrenareshownbelow.

Normal17-OHPserumvaluesforinfantsandchildren17-OH-Progesteronein195seraofinfants
17-OH-Progesteronein139seraofchildren

Thisproductrepresentstherightalternativetothesoondiscontinued17-aOH-ProgesteroneCACRIAfromSiemens.Pleasecontactusifyoushouldneedanykitfortrialpurposes!Orifyoushouldneedanysupportregardingcomparisonstudies.Wewillbehappytoprovideyouwithexpectedhelp.

ExcellentreplacementforRIA

AvalidationstudybytheAustralianlaboratoryACTshowsthatIBL’s17-OH-ProgesteroneELISAprovidesanexcellentalternativefortheSiemensHealthcareDiagnostics(formerlyDPC)17-aOH-ProgesteroneRIA.Thedatacanviewedhere:
EscapefromRIA-ACTPoster2013
Pleasecontactusifyouwouldbeinterestedtoperformyourowninternalvalidationstudy.

HighcorrelationtoGC-MS/MSshowninExternalQualityAssessmentScheme

ThelatestsurveystudybytheReferenceforBioanalyticsinBonn,Germany,againconfirmedthecorrectcalibrationandreliABIlityofourassay.
RfBsurveyresults

ExcerptfromtheInstructionsforUse
Enzymeimmunoassayforthein-vitro-diagnosticquantitativedeterminationof17-OH-Progesteroneinhumanserumandplasma.17-OH-progesterone(17-OHP)isthemostsuitablebiochemicalmarkerforthediagnosisofCongenitalAdrenalHyperplasia(CAH).CAHhasaprevalenceofaround1-20in10,000childrenandisoneofthemostfrequentinbornendocrinedisorders.Thespectrumofclinicalpresentationsrangesfromformswithneonatalsymptoms,i.e.saltwastingandsimplevirilizingforms,tonon-classicalformsthatmightnotmanifestuntiladulthood.MeasuringthissteroidenablesearlydiagnosisandtreatmentinpatientssufferingfromCAH.17-OHPissecretedinabundantexcessinaffectedinfantsdueto21-hydroxylasedeficiency.Femalepatientswithlate-onsetCAHusuallyhave17-OHPconcentrationsabovethereferenceintervalforthefollicularphaseofthemenstrualcycle.