产品资料

Novus/Caspase-3 Antibody (269518) [Unconjugated] - Cleaved (Asp175) (MAB835)/MAB835-SP/25 ug

Summary:

Immunogen	KLH-conjugatedhumanCaspase-3syntheticpeptide CRGTELDCGIETD Accession#U26943
Specificity	DetectshumanandmouseCaspase-3cleavedatAsp175.Nocross-reactivitywasdetectedwiththefull-lengthprocaspase-3orothercaspases.
Source	N/A
Isotype	IgG
Clonality	Monoclonal
Host	Rabbit
Gene	CASP3
Innovator"sReward	Testinaspecies/applicationnotlistedabovetoreceiveafullcredittowardsafuturepurchase. LearnabouttheInnovator"sReward

Applications/Dilutions:

Dilutions

WesternBlot0.5ug/mL
Immunocytochemistry8-25ug/mL

ReviewedApplications

Read4Reviewsrated4.5

using
MAB835inthefollowingapplications:

WesternBlot
Immunofluorescence
Immunohistochemistry-Paraffin

Publications

ReadPublicationsusing
MAB835inthefollowingapplications:

ICC
1publication
IF
1publication
IHC
4publications
IHCFrozen
2publications
IHC-Notspecified
1publication
IHCFresh
1publication
IHCFrozen
3publications
IHCParaffin-embedded
2publications
IHCparaffinembedded
1publication
WB
8publications

Packaging,Storage&Formulations:

ThisproductisproducedbyandshipsfromR&DSystems,Inc.,aBio-Technebrand.

Notes:

Apopain
apoptosis-relatedcysteineprotease
CASP3
CASP-3
caspase3,apoptosis-relatedcysteinepeptidase
Caspase3
Caspase-3
CPP32
CPP-32
CPP32B
CPP32SREBPcleavageactivity1
CysteineproteaseCPP32
EC3.4.22
EC3.4.22.56
LICE-1
PARPcleavageprotease
procaspase3
ProteinYama
SCA-1
YAMA

AlternateNamesfor53BP1Antibody:

Caspase-3(Cysteine-asparticacidprotease3/Casp3;alsoYama,apopainandCPP32)isa29kDaheterodimerthatbelongstothepeptidaseC14Afamilyofenzymes.Itiswidelyexpressedandconsideredtobethemajorexecutionercaspaseintheapoptoticcascade.Humanprocaspase-3isa32kDa,277aminoacid(aa)proteinandisnormallyaninactivehomodimer.Followingcellstress/activation,procaspase-3undergoesproteolysistogenerateanN-terminal148aap17/17kDasubunit(aa29-175),plusa102aaC-terminalp12/12kDasubunit.Thesesubunitsnoncovalentlyheterodimerize,andassociatewithanotherp17/p12heterodimertoformanactiveenzyme.Thereisonepotentialvariantthatshowsanalternativestartsitenineaaupstreamofthestandardstartsitecoupledwitha21aasubstitutionforaa162-277.Overaa29-175,humanandmousecaspase-3share87%aaidentity.

Background:

Thisproductisforresearchuseonlyandisnotapprovedforuseinhumansorinclinicaldiagnosis.PrimaryAntibodiesareguaranteedfor1yearfromdateofreceipt.

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