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| Description | FUNCTION:Thisisaspecificreceptorforparathyroidhormone.Theactivityofthisreceptorismediatedbygproteinswhichactivateadenylylcyclase.PTHR2mayberesponsIBLeforPTHeffectsinanumberofphysiologicalsystems.Itmayplayasignificantroleinpancreaticfunction.PTHR2presenceinneuronsindicatesthatitmayfunctionasaneurotransmitterreceptor.SUBUNIT:BindstoTIPF39/TIP39.SUBCELLULARLOCATION:Membrane;multi-passmembraneprotein.TISSUESPECIFICITY:Abundantlyexpressedinbrain,arterialandcardiacendothelium.Foundaswellinsperm,intheheadoftheepididymis.Lowerexpressionisfoundinvascularsmoothmuscle,exocrinepancreas,testisandplacenta.SIMILARITY:BelongstotheG-proteincoupledreceptor2family. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(RQIDSHVTLPGYVWSSSEQDC)ofratParathyroidhormonereceptorprotein(aa:481-501)conjugatedtoKLHhasbeenusedastheimmunogen. |
| OtherNames | Parathyroidhormonereceptor;PTH2receptor;Pthr2; |
| Accession | PTHR2_RAT |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | WB.Adilutionof1:500to1:1000isrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Specificityhasbeenshownbywesternblot.Abandof63kDacorrespondingtothetheoreticalmolecularweightofParathyroidhormonereceptoriseasilydetectablebyWB.AbsorptionoftheantiserumwiththeimmunisingpeptideabolishedthebindingoftheantibodytothetargethencedetectABIlityoftheband. |
| Cross-reactivity | ThisantibodyisknowntoreactwithratParathyroidhormonereceptor. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstability,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| References | Usdin,T.B.etal.(1999).Endocrinology.140(7):3363. |
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