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| Description | GDNFisaglycosylated,disulfide-bondedhomodimermolecule.ItwasfirstdiscoveredasapotentsurvivalfactorformidbraindopaminergicneuronsandwasthenshowntorescuetheseneuronsinanimalmodelsofParkinson"sdisease.GDNFisabout100timesmoreefficientsurvivalfactorforspinalmotorneuronsthantheneurotrophins.FUNCTION:Neurotrophicfactorthatenhancessurvivalandmorphologicaldifferentiationofdopaminergicneuronsandincreasestheirhigh-affinitydopamineuptake.SUBUNIT:Homodimer;disulfide-linked.SUBCELLULARLOCATION:Secretedprotein.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.DISEASE:DefectsinGDNFmaybeacauseofHirschsprungdisease(HSCR).InassociationwithmutationsofRETgene,defectsinGDNFmaybeinvolvedinHirschsprungdisease.Thisgeneticdisorderofneuralcrestdevelopmentischaracterizedbytheabsenceofintramuralganglioncellsinthehindgut,oftenresultinginintestinalobstruction.DISEASE:DefectsinGDNFareacauseofcongenitalcentralhypoventilationsyndrome(CCHS);alsoknownascongenitalfailureofautonomiccontrolorOndinecurse.CCHSisararedisordercharacterizedbyabnormalcontrolofrespirationintheabsenceofneuromuscularorlungdisease,oranidentifiablebrainstemlesion.AdeficiencyinautonomiccontrolofrespirationresultsininadequateornegligIBLeventilatoryandarousalresponsestohypercapniaandhypoxemia.SIMILARITY:BelongstotheTGF-betafamily.GDNFsubfamily. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | RecombinanthumanGDNF |
| OtherNames | Glialcellline-derivedneurotrophicfactor;Astrocyte-derivedtrophicfactor;ATF;GDNF |
| Accession | GDNF_HUMAN |
| Producedin | Sheep |
| Purity | Wholeserum |
| Applications | WB.Recommendedtobeusedatadilutionof1:1000to1:3000forWesternblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | NocrossreactivitywithNTNhasbeenobservedinwesternblotanalysis. |
| Cross-reactivity | Thisantibodyisknowntoreactwithhuman,mouseandratGDNF. |
| Blastit | IfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| References | Linetal.(1993)Science.260(5111):1130-2 |
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