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Prospec/SUMO1 Human His/PRO-980/5µg

Cataloguenumber

PRO-980

Synonyms

Smallubiquitin-relatedmodifier1,SUMO-1,Sentrin,Ubiquitin-likeproteinSMT3C,SMT3homolog3,Ubiquitin-homologydomainproteinPIC1,Ubiquitin-likeproteinUBL1,GAP-modifyingprotein1,GMP1,SUMO1,SMT3C,SMT3H3,UBL1,PIC1,SMT3,DAP-1,OFC10,SENP2.

Introduction

SUMO1isaproteinthatbelongstotheSUMO(smallubiquitin-likemodifier)proteinfamily.SUMO1functionsinamannersimilartoubiquitininthatitisboundtotargetproteinsaspartofapost-translationalmodificationsystem.Still,unlikeubiquitinwhichtargetsproteinsfordegradation,SUMO1isinvolvedinavarietyofcellularprocesses,forexamplenucleartransport,transcriptionalregulation,apoptosis,andproteinstABIlity.SUMO1isnotactiveuntilthelastfouraminoacidsofthecarboxy-terminusarecleavedoff.

Description

SUMO1HumanRecombinantproducedinE.coliisasingle,non-glycosylatedpolypeptidechaincontaining109aminoacids(1-101)andhavingamolecularmassof12.6kDa.
SUMO1isfusedtoa8aminoacidHis-tagatC-terminus&purifiedbyproprietarychromatographictechniques.

Source

E.coli.

PhysicalAppearance

SterileFilteredcolorlesssolution.

Formulation

TheSUMO1solution(1mg/1ml)contains20mMTris-HClbuffer(pH8.0),1mMDTT,0.15MNaCland10%glycerol.

Stability

Storeat4°Cifentirevialwillbeusedwithin2-4weeks.Store,frozenat-20°Cforlongerperiodsoftime.
Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).
Avoidmultiplefreeze-thawcycles.

Purity

Greaterthan90%asdeterminedbySDS-PAGE.

Aminoacidsequence

MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTVLEHHHHHH

Usage

Prospec"sproductsarefurnishedforLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.
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