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InvivoGen/Pepinh-TRIF/2 mg/tlrl-pitrif

Pepinh-TRIF

Pepinh-TRIF	Unit size	Cat. code	Docs	Price
TRIF inhibitory peptide	2 mg	tlrl-pitrif	TDSMSDS	￥8,103.00 Please contact our distributor Add to favorite

About
Specifications
Contents
Citations

TRIF inhibitory peptide

Pepinh-TRIF is a 30 aa peptide that blocks TRIF signaling by interfering with TLR-TRIF interaction.

PepinhTRIF contains the 14 aa that correspond to the sequence of the BB loop of TRIF (FCEEFQVPGRGELH) [1] linked to the cell-penetrating segment of the antennapedia homoedomain (RQIKIWFQNRRMKWKK) [2].

Pepinh TRIF is provided with Pepinh-Control, a control peptide [1].

References:

1. Toshchakov V. et al., 2005. Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction. J. Immunol., 175: 494 - 500.2. Derossi D. et al., 1994. The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem., 269: 10444-50.

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Specifications

Working concentration: 5-50 μM

Purity: ≥95% (UHPLC)

Species reactivity: Human, mouse

Sequences:

Pepinh-TRIF: RQIKIWFQNRRMKWKK-FCEEFQVPGRGELH-NH2

(TRIF homodimerization sequence is underlined)

Pepinh-Control: RQIKIWFQNRRMKWKK-SLHGRGDPMEAFII-NH2

Molecular weights:

Pepinh-TRIF: 3918
Pepinh-Control: 3812

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Pepinh-TRIF is provided as a white solid .

2 mg of lyophilized Pepinh-TRIF
2 mg of lyophilized Pepinh-Control
2x1.5 ml endotoxin-free water

Pepinh-TRIF is shipped at room temperature.

Store at -20°C.

Solid product is stable 1 year at -20°C.

Upon resuspension, Pepinh-TRIF should be aliquoted and stored at -20°C.

Avoid repeated freeze-thaw cycles.

Resuspended product is stable for 6-8 months at -20°C when properly stored.

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Citations

2019 BJC DOI: 10.1038/s41416-019-0595-2

Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.

Chen Q. et al.

2018 J Immunol. 200(10):3599-3611.

The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation.

Ahmad R. et al.

2012 J Neurosci. 32(22):7745-7757

Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β mediates microglial phagocytosis of degenerating axons.

Hosmane S, Tegenge MA, Rajbhandari L, Uapinyoying P, Kumar NG, Thakor N, Venkatesan A

2011 PLoS ONE 6(9):e25504

Leukocyte- and platelet-derived microvesicle interactions following in vitro and in vivo activation of toll-like receptor 4 by lipopolysaccharide.

Xiong J, Miller VM, Hunter LW, Li Y, Jayachandran M

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InvivoGen/Pepinh-TRIF/2 mg/tlrl-pitrif

Pepinh-TRIF

TRIF inhibitory peptide

Specifications

Contents

Citations

Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.

The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation.

Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β mediates microglial phagocytosis of degenerating axons.

Leukocyte- and platelet-derived microvesicle interactions following in vitro and in vivo activation of toll-like receptor 4 by lipopolysaccharide.