| Description | ThedsDNAIgGELISAtestsystemisanenzymelinkedimmunosorbentassay(ELISA)forthedetectionofIgGclassantibodiestodsDNAinhumanserumorplasma.Anti-dsDNAispresentin50%to70%ofpatientswithsystemiclupuserythematosus(SLE).CirculatingDNA/anti-DNAimmunecomplexesareconsideredtoplayapartinthepathogenesisofSLE.Thepresenceofanti-dsDNAisoneofthediagnosticcriteriaforSLE.IgGantibodiestodsDNAareconsideredclinicallymostusefulforthediagnosisandmanagementofSLE.AntibodiestosinglestrandedDNA(ssDNA)andIgMantibodiestoDNAarefoundinanumberofotherconnectivediseases,liverdiseases,aswellasinsomenormalindividuals.ELISAisthemethodofchoiceforthescreeningofanti-dsDNAin-patientswithsuspectedSLE. |
|---|---|
| Species | Human |
| SampleType | SerumorPlasma |
| Name | dsDNAIgGELISA |
|---|---|
| ShortDescription | ThedsDNAIgGELISAtestsystemisanenzymelinkedimmunosorbentassay(ELISA)forthedetectionofIgGclassantibodiestodsDNAinhumanserumorplasma.Anti-dsDNAispresentin50%to70%ofpatientswithsystemiclupuserythematosus(SLE).CirculatingDNA/anti-DNAimmunecomplexesareconsideredtoplayapartinthepathogenesisofSLE.Thepresenceofanti-dsDNAisoneofthediagnosticcriteriaforSLE.IgGantibodiestodsDNAareconsideredclinicallymostusefulforthediagnosisandmanagementofSLE.AntibodiestosinglestrandedDNA(ssDNA)andIgMantibodiestoDNAarefoundinanumberofotherconnectivediseases,liverdiseases,aswellasinsomenormalindividuals.ELISAisthemethodofchoiceforthescreeningofanti-dsDNAin-patientswithsuspectedSLE. |
| Reactivity | Human |