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GenWay/Thyroid Peroxidase (TPO) IgG ELISA/GWBBQK174/96 Well Plate188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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GenWay/Thyroid Peroxidase (TPO) IgG ELISA/GWBBQK174/96 Well Plate

Description:

DescriptionTheThyroidPeroxidase(TPO)IgGELISAtestsystemisanenzymelinkedimmunosorbentassay(ELISA)forthedetectionofIgGclassantibodiestoThyroidPeroxidaseinhumanserumorplasma.Thyroidperoxidase(TPO),isthemajorautoantigen(933aminoacidresidue)inthethyroidmicrosomalantigen(TMA)particle.ThepurificationandpreparationofthisantigenhasmadetestingforTMAantibodiesobsolete.ELISAusingTPOrecombinantantigenisthemostpopularassay.DetectionofTPOantibodiesisstrongevidenceagainstagoiterornon-autoimmunecausesofhypothyroidism.Theannualriskforthedevelopmentofhypothyroidismis3%to4%peryearifTPOantibodiesarepresentandTSHiselevated.TPOantibodiesarepresentin8-9%normalcontrols,57-74%patientswithGravesdisease,99-100%ofHashimotodiseaseoridiopathicmyxedema,19%withdifferentiatedthyroidcancer,nopatientswithsubacutethyroiditisand11%ofthosewithothermiscellaneousnon-autoimmunethyroiddiseases.TheprevalenceofpositiveTPOantibodiesishigherinelderly(meanage80years)women(10%)comparedtoelderlymen(2%).Autoantibodyconcentrationincentenariansalsodecreases.StudiesofTPOepitopesineachdomain,AandB,anddetectionoftheirspecificautoantibodiessuggestthattheepitope-specificTPOantibodiesratio(A/B)doesnotchangeovertimeinindividualpatientsandthatTPOepitopeautoantibodypatternsmaybeinherited.
SpeciesHuman
SampleTypeSerumorPlasma

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NameThyroidPeroxidase(TPO)IgGELISA
ShortDescriptionTheThyroidPeroxidase(TPO)IgGELISAtestsystemisanenzymelinkedimmunosorbentassay(ELISA)forthedetectionofIgGclassantibodiestoThyroidPeroxidaseinhumanserumorplasma.Thyroidperoxidase(TPO),isthemajorautoantigen(933aminoacidresidue)inthethyroidmicrosomalantigen(TMA)particle.ThepurificationandpreparationofthisantigenhasmadetestingforTMAantibodiesobsolete.ELISAusingTPOrecombinantantigenisthemostpopularassay.DetectionofTPOantibodiesisstrongevidenceagainstagoiterornon-autoimmunecausesofhypothyroidism.Theannualriskforthedevelopmentofhypothyroidismis3%to4%peryearifTPOantibodiesarepresentandTSHiselevated.TPOantibodiesarepresentin8-9%normalcontrols,57-74%patientswithGravesdisease,99-100%ofHashimotodiseaseoridiopathicmyxedema,19%withdifferentiatedthyroidcancer,nopatientswithsubacutethyroiditisand11%ofthosewithothermiscellaneousnon-autoimmunethyroiddiseases.TheprevalenceofpositiveTPOantibodiesishigherinelderly(meanage80years)women(10%)comparedtoelderlymen(2%).Autoantibodyconcentrationincentenariansalsodecreases.StudiesofTPOepitopesineachdomain,AandB,anddetectionoftheirspecificautoantibodiessuggestthattheepitope-specificTPOantibodiesratio(A/B)doesnotchangeovertimeinindividualpatientsandthatTPOepitopeautoantibodypatternsmaybeinherited.
ReactivityHuman