MedKoo Biosciences/Panobinostat/202151/500mg

Synonym:LBH589;LBH589;LBH-589;NVP-LBH589;NVP-LBH589;Panobinostat;tradenameFarydak

IUPAC/ChemicalName:(2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide

InChiKey:FPOHNWQLNRZRFC-ZHACJKMWSA-N

InChiCode:InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+

SMILESCode:O=C(NO)/C=C/C1=CC=C(CNCCC2=C(C)NC3=C2C=CC=C3)C=C1

TechnicalData

AdditionalInformation

PanobinostathasbeenfoundtosynergisticallyactwithsirolimustokillpancreaticcancercellsinthelaboratoryinaMayoClinicstudy.Inthestudy,investigatorsfoundthatthiscombinationdestroyedupto65percentofculturedpancreatictumorcells.Thefindingissignificantbecausethethreecelllinesstudieswereallresistanttotheeffectsofchemotherapy–asaremanypancreatictumors.seehttp://en.wikipedia.org/wiki/Panobinostat. 
 
 

References

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2:LiX,ZhangJ,XieY,JiangY,YingjieZ,XuW.ProgressofHDACinhibitorpanobinostatinthetreatmentofcancer.CurrDrugTargets.2014Jun;15(6):622-34.Review.PubMedPMID:24597570.

3:AnneM,SammartinoD,BarginearMF,BudmanD.Profileofpanobinostatanditspotentialfortreatmentinsolidtumors:anupdate.OncoTargetsTher.2013Nov15;6:1613-24.doi:10.2147/OTT.S30773.eCollection2013.Review.PubMedPMID:24265556;PubMedCentralPMCID:PMC3833618.

4:KhotA,DickinsonM,PrinceHM.Panobinostatinlymphoidandmyeloidmalignancies.ExpertOpinInvestigDrugs.2013Sep;22(9):1211-23.doi:10.1517/13543784.2013.815165.Epub2013Jul3.Review.PubMedPMID:23826641.

5:NeriP,BahlisNJ,LonialS.Panobinostatforthetreatmentofmultiplemyeloma.ExpertOpinInvestigDrugs.2012May;21(5):733-47.doi:10.1517/13543784.2012.668883.Epub2012Mar12.Review.PubMedPMID:22404247.

6:OkiY,CopelandA,YounesA.ClinicaldevelopmentofpanobinostatinclassicalHodgkin'slymphoma.ExpertRevHematol.2011Jun;4(3):245-52.doi:10.1586/ehm.11.24.Review.PubMedPMID:21668391.

7:PrinceHM,BishtonMJ,JohnstoneRW.Panobinostat(LBH589):apotentpan-deacetylaseinhibitorwithpromisingactivityagainsthematologicandsolidtumors.FutureOncol.2009Jun;5(5):601-12.doi:10.2217/fon.09.36.Review.PubMedPMID:19519200.

8:AtadjaP.Developmentofthepan-DACinhibitorpanobinostat(LBH589):successesandchallenges.CancerLett.2009Aug8;280(2):233-41.doi:10.1016/j.canlet.2009.02.019.Epub2009Apr2.Review.PubMedPMID:19344997.