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| Serum-SalivaCorrelation | NA | ||||||||
Sensitivity
| |||||||||
| SampleTestVolume | 25μL | ||||||||
| RecommendedCollectionVolume | 100μL | ||||||||
| SpecialConsiderations | No | ||||||||
| CollectionProtocol | DownloadPDF | ||||||||
ThesalimetricscytokinepanelmeasuresIL-1β,IL-6,IL-8&TNF-αconcentrationssimultaneouslyusingasingle,100µlsalivasampleandfeaturesconvenientpanelpricing.Smallsamplevolumescanbeespeciallybeneficialforinfant,children,oranimalstudiesandforresearchwhereinvestigatorsareroutinelylimitedintheamountofsalivathatcanbecollected.
IL-1β,IL-8andTNF-αarethreeimportantexamplesofaclassofsignalingmoleculesknownaspro-inflammatorycytokines,whichplayanimportantroleininitiatingthebody’sacutephaseinflammatoryresponsetoinfections,injuries,orpossIBLystress.IL-1βandtoalesserextentTNF-α,havebeenstronglyassociatedwithoralinflammatoryconditionsincludinggingivitisandperiodontaldisease.Theseconditionsplayalargerroleinmoreseveresystemicdiseasessuchascardiovasculardiseaseanddiabetes.IL-6alsoinducestheproductionofC-reactiveprotein(CRP)intheliver,whichwhenelevatedchronicallycanleadtoobesity.Importantly,severalreportsindicatethatallfourcytokinesmaycontributetothepathogenesisofcertainoralcancersandhavebeenimplicatedasMarkersforearlyoralcancerdetection.Therefore,inadditiontotheirutilityinassessingoralinflammation,thesemarkersmayalsobeofinterestinotherfields,includingcancer,asthma,andstressresearch.
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