Serum-SalivaCorrelation | NA |
Sensitivity | 1pg/mL |
SampleTestVolume | 100μL |
RecommendedCollectionVolume | 225μL* |
SpecialConsiderations | No |
CollectionProtocol | DownloadPDF |
Estrone(3-hydroxy-1,3,5(10)-estratrien-17-one;E1)isoneofthethreemainestrogenicsteroidhormonesproducedinhumans.Circulatingestronelevelsarerelativelyhighatbirthinbothmalesandfemales,decreasepostnatally,andincreaseduringpuberty.(1)Ofthethreemajorestrogens,estroneispredominantaftermenopauseinwomen.(1)
Inpremenopausalwomenestroneisprimarilyproducedbyconversionofandrostenedioneintheovaries,withconcentrationspeakinginthepreovulatoryphaseandasmallersecondaryincreaseduringthelutealphase.(1,2)Inpost-menopausalwomen,children,andmen,estroneislargelyproducedbyconversionofandrostenedioneinperipheraltissues.(1,2,3)EstroneissubsequentlyreducedtoestrADIolinvariousperipheraltissues.(3)
Innon-pregnantwomen,onlyabout3%ofestroneinthebloodstreamisnotboundtoproteins.(4)Unboundestroneenterssalivafrombloodviaintracellularmechanisms,andinsalivathemajorityoftheestroneremainsunboundtoprotein.Thesalivaandplasmavaluesarehighlycorrelated.(5)
SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg
vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit
vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg
GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn