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ubpbio/6xHisUbe2D3 (UbcH5C)/C1601/100 µg

Ube2D3isanE2enzyme,whichispartoftheE1,E2,andE3cascaderesponsIBLeforubiquitinationofproteinsubstrates.Ube2D3is88%identicaltotheaminoacidsequenceofUbe2D1.Ube2D3workswithMdm2(anE3ligase)toubiquitinateandregulateproteinlevelsofp53andMdm2.Ube2D3hasbeenlinkedtocadminumtoxicity.ItmightalsoplayaroleinLDLcholesterolreceptorubiquitinationinanIdol-dependentfashion.

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Ube2D3isanE2enzyme,whichispartoftheE1,E2,andE3cascaderesponsibleforubiquitinationofproteinsubstrates.Ube2D3is88%identicaltotheaminoacidsequenceofUbe2D1.Ube2D3workswithMdm2(anE3ligase)toubiquitinateandregulateproteinlevelsofp53andMdm2.Ube2D3hasbeenlinkedtocadminumtoxicity.ItmightalsoplayaroleinLDLcholesterolreceptorubiquitinationinanIdol-dependentfashion.
Images:(Clickimagetoenlarge)
ProductName:6xHis-Ube2D3(UbcH5C)
AlsoKnownAs:UBC4/5;UBCH5C;E2(17)KB3
CatalogNo.:C1601
Size:100µg
MolecularWeight:16.7kDa
Species:Human
Source:Bacterialrecombinant
Stock:20mMTris,150mMNaCl,2mMβME,10%Glycerol
Concentration:Seetubelabel
QualityAssurance:~95%bySDS-PAGE,seedatasheetforgelimage
Storage:Storeat-80°C;avoidmultiplefreeze-thawcycles
PDFDataSheet:PDFDatasheetMSDS
NCBIRefSeq:NM_003340
Image(s):(Clickimagetoenlarge)
Coomassie-stainedSDS-PAGE
Lane1:MolecularweightMarkers
Lane2:5µgpurified6xHis-Ube2D3(UbcH5C)
ShippingMethod:Dryiceshipping
References:1.ScheffnerM,etal.(1994)ProcNatlAcadSciUSA91,8797–8801.
2.JensenJP,etal.(1995)JBiolChem270(51),30408–30414.3.SavilleMK,etal.(2004)JBiolChem279,42169–42181.
4.TokumotoM,etal.(2011)JToxicolSci36(2),191–200.5.ZhangL,etal.(2011)GenesDev25,1262–1274.
Coomassie-stainedSDS-PAGE
Lane1:Molecularweightmarkers
Lane2:5µgpurified6xHis-Ube2D3(UbcH5C)

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