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ubpbio/GSTNEMO (L329P)/I1511/100 µg
NF-κBessentialmodulator(NEMO)isaregulatorysubunitwithinIκBkinase(IKK).IKKisalsocomposedoftwounrelatedcatalyticsubunitscalledIKKαandIKKβ.NEMOisadditionallyreferredtoasIKKγ,IKKAP1,orFIP-3.IKKisresponsibleforactivatingthetranscriptionfactor,NF-κB,whichisinvolvedinimmuneresponse.NEMOpreferstobindK63-linkedorlinearpolyubiquitinchains.

TheL329PsubstitutionabolishesNEMOinteractswithlinearpolyUbchainsandlongK63polyubiquitinchains.

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NF-κBessentialmodulator(NEMO)isaregulatorysubunitwithinIκBkinase(IKK).IKKisalsocomposedoftwounrelatedcatalyticsubunitscalledIKKαandIKKβ.NEMOisadditionallyreferredtoasIKKγ,IKKAP1,orFIP-3.IKKisresponsibleforactivatingthetranscriptionfactor,NF-κB,whichisinvolvedinimmuneresponse.NEMOpreferstobindK63-linkedorlinearpolyubiquitinchains.
TheL329PsubstitutionabolishesNEMOinteractswithlinearpolyUbchainsandlongK63polyubiquitinchains.
Images:(Clickimagetoenlarge)
ProductName:GST-NEMO(L329P)
AlsoKnownAs:IKBKG;IP;IP1;IP2;FIP3;IPD2;NEMO;FIP-3;Fip3p;AMCBX1;ZC2HC9;IKK-gamma
CatalogNo.:I1511
Size:100µg
MolecularWeight:48.2kDa
Species:Human
Source:Bacterialrecombinant
Stock:20mMTris,150mMNaCl,2mMβME,10%Glycerol
Concentration:Seetubelabel
QualityAssurance:~80%bySDS-PAGE,seedatasheetforgelimage
Storage:Storeat-80°C;avoidmultiplefreeze-thawcycles
PDFDataSheet:PDFDatasheet，MSDS
NCBIRefSeq:NM_001099857
Image(s):(Clickimagetoenlarge)
Coomassie-stainedSDS-PAGE
Lane1:MolecularweightMarkersLane2:5µgpurifiedGST-NEMO(L329P)
ShippingMethod:Dryiceshipping
References:1.RothwarfDM,etal.(1998)Nature395,297–300.
2.YamaokaS,etal.(1998)Cell93,1231–1240.3.GhoshS,KarinM(2002)Cell109Suppl,S81–96.
Coomassie-stainedSDS-PAGE
Lane1:MolecularweightmarkersLane2:5µgpurifiedGST-NEMO(L329P)

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