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ubpbio/IU1/F4101/25 mg
IU1isareversibleandspecificinhibitorofproteasome-associatingUsp14.Itdoesnotinhibitotherdeubiquitinatingenzymesofthe26Sproteasome.Itpartiallyinhibitstheubiquitinchaintrimmingactivityofthe26Sproteasome,whichcouldfunctiontostimulatethedegradationofsomeproteasomalsubstrates.

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IU1isareversibleandspecificinhibitorofproteasome-associatingUsp14.Itdoesnotinhibitotherdeubiquitinatingenzymesofthe26Sproteasome.Itpartiallyinhibitstheubiquitinchaintrimmingactivityofthe26Sproteasome,whichcouldfunctiontostimulatethedegradationofsomeproteasomalsubstrates.

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EqualamountofwholecelllysatespreparedfromDMSO(lane1)or75μMIU1(lane2)-treatedHeLacellswereseparatedbySDS-PAGEandimmunoblottedwithananti-Ubantibody.HEK293TCellsweretreatedwithDMSOorIU1for5hours.

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ProductName:IU1
AlsoKnownAs:1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone;CAS#:314245-33-5
CatalogNo.:F4101
Size:25mg
MolecularWeight:300.4Da
Species:N/A
Source:Synthetic
Stock:Powder
Concentration:N/A
QualityAssurance:>98%byHPLCandNMR
Storage:Eligibleforroomtemperatureshipping.Storeat-80°Cuponreceiving;avoidmultiplefreeze-thawcyclesafterdissolvinginDMSO.
PDFDataSheet:DownloadPDFdatasheet
NCBIRefSeq:N/A
Image(s):No
ShippingMethod:Roomtemperatureshipping
References:LeeBHetal.(2010)Nature,467,179-184