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ubpbio/PR-619/F2111/50 mg

Acell-permeablepandeubiquitinatingenzymeinhibitorthatisknowntoinhibitATXN3,BAP1,JOSD2,OTUD5,UCH-L1,UCH-L3,UCH-L5/UCH37,USP1,2,4,5,7,8,9X,10,14,15,16,19,20,22,24,28,47,48,VCIP135,YOD1,aswellasdeISGylasePLpro,deNEDDylaseDEN1,anddeSUMOlyaseSENP6.PR-619inhibitsmanydeubiquitinatingenzymesinthe5-20µMrange.TreatingcellswithPR-619resultsintheaccumulationofbothubiquitinandsumo-conjugatedproteins.

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Acell-permeablepandeubiquitinatingenzymeinhibitorthatisknowntoinhibitATXN3,BAP1,JOSD2,OTUD5,UCH-L1,UCH-L3,UCH-L5/UCH37,USP1,2,4,5,7,8,9X,10,14,15,16,19,20,22,24,28,47,48,VCIP135,YOD1,aswellasdeISGylasePLpro,deNEDDylaseDEN1,anddeSUMOlyaseSENP6.PR-619inhibitsmanydeubiquitinatingenzymesinthe5-20µMrange.TreatingcellswithPR-619resultsintheaccumulationofbothubiquitinandsumo-conjugatedproteins.
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ProductName:PR-619
AlsoKnownAs:(2,6-diamino-5-thiocyanatopyridin-3-yl)thiocyanate;CAS#2645-32-1;C7H5N5S2
CatalogNo.:F2111
Size:50mg
MolecularWeight:223.28Da
Species:N/A
Source:Synthetic
Stock:Powder
Concentration:N/A
QualityAssurance:≥98%byHPLC
Storage:EligIBLeforroomtemperatureshipping.Storeat-20°Cuponreceiving;protectfromairandlight
PDFDataSheet:PDFDatasheet
NCBIRefSeq:N/A
Image(s):N/A
ShippingMethod:Roomtemperatureshipping
References:1.TianX.,etal.(2011)AssayDrugDevTechnol.9(2):165-73.
2.SeiberlichV.,etal.(2012)BiochimBiophysActa.1823(11):2057-68.