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ubpbio/6xHisUbe2T/C3800/25 µg

Ube2TisanE2enzyme,whichispartoftheE1,E2,andE3cascaderesponsibleforubiquitinationofproteinsubstrates.Ube2TinteractswiththeE3ligasecalledFanconianemiacomplementationgroupL(FANCL)thatispartofalargercomplextoregulateDNAdamagerepair.OnceFANCLinteractswithUbe2T,thecomplexisthenabletomonoubiquitinateFANCD2thatleadstotheDNArepair.Ube2TcanalsointeractwiththeBRCA1/BARD1complex.

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Ube2TisanE2enzyme,whichispartoftheE1,E2,andE3cascaderesponsibleforubiquitinationofproteinsubstrates.Ube2TinteractswiththeE3ligasecalledFanconianemiacomplementationgroupL(FANCL)thatispartofalargercomplextoregulateDNAdamagerepair.OnceFANCLinteractswithUbe2T,thecomplexisthenabletomonoubiquitinateFANCD2thatleadstotheDNArepair.Ube2TcanalsointeractwiththeBRCA1/BARD1complex.
Images:(Clickimagetoenlarge)
ProductName:6xHis-Ube2T
AlsoKnownAs:PIG50;HSPC150
CatalogNo.:C3800
Size:25µg
MolecularWeight:22.5kDa
Species:Human
Source:Bacterialrecombinant
Stock:20mMTris,150mMNaCl,2mMβME,10%Glycerol
Concentration:Seetubelabel
QualityAssurance:~90%bySDS-PAGE,seedatasheetforgelimage
Storage:Storeat-80°C;avoidmultiplefreeze-thawcycles
PDFDataSheet:PDFDatasheetMSDS
NCBIRefSeq:NM_014176
Image(s):(Clickimagetoenlarge)
Coomassie-stainedSDS-PAGE
Lane1:MolecularweightMarkers
Lane2:5µgpurified6xHis-Ube2T
ShippingMethod:Dryiceshipping
References:1.ZhangQH,etal.(2000)GenomeRes10,1546–1560.
2.MachidaYJ,etal.(2006)MolCell23,589-96.
3.HaoJ,etal.(2008)TumourBiol29,195–203.
4.UekiT,etal.(2009)CancerRes69(22),8752–8760.
Coomassie-stainedSDS-PAGE
Lane1:Molecularweightmarkers
Lane2:5µgpurified6xHis-Ube2T

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