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ubpbio/Noncleavable K48 PolyUb Chain <sub>(26)</sub>/D1601/100 µg
UbchainsareformedbyconjugatingtheC-terminalglycineresidueofUbontoanyofseveninternallysineresiduesortheaminogroupofthepreviousUb.UbchainsareclassifiedbythelysineresidueusedtolinkUbs;differentUbchaintopologiescanresultindifferentsignals.Forinstance,Ubchainslinkedthroughlysine6,11,27,29,33and48arecapableoftargetingproteinsforproteasomaldegradation;incontrast,Ubchainslinkedthroughlysine63ortheN-terminalaminogroup(linearUbchains)oftenplayimportantnonproteolyticfunctionsincludingregulationofkinaseactivationandproteintranslation.AllUbchainproductsareproducedbyusingofhumanwildtypeUbreactingwithspecificE2s.

Non-cleavableK48polyUbchainsaremadeoftheUb(L73P)mutant.

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UbchainsareformedbyconjugatingtheC-terminalglycineresidueofUbontoanyofseveninternallysineresiduesortheaminogroupofthepreviousUb.UbchainsareclassifiedbythelysineresidueusedtolinkUbs;differentUbchaintopologiescanresultindifferentsignals.Forinstance,Ubchainslinkedthroughlysine6,11,27,29,33and48arecapableoftargetingproteinsforproteasomaldegradation;incontrast,Ubchainslinkedthroughlysine63ortheN-terminalaminogroup(linearUbchains)oftenplayimportantnonproteolyticfunctionsincludingregulationofkinaseactivationandproteintranslation.AllUbchainproductsareproducedbyusingofhumanwildtypeUbreactingwithspecificE2s.Non-cleavableK48polyUbchainsaremadeoftheUb(L73P)mutant.

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ProductName:Non-cleavableK48PolyUbChain(2-6)
AlsoKnownAs:N/A
CatalogNo.:D1601
Size:100µg
MolecularWeight:N/A
Species:Human
Source:Bacterialrecombinant
Stock:20mMTris,150mMNaCl,2mMβME,10%Glycerol
Concentration:Seetubelabel
QualityAssurance:~95%bySDS-PAGE,seedatasheetforgelimage
Storage:Storeat-80°C;avoidmultiplefreeze-thawcycles
PDFDataSheet:PDFDatasheet，MSDS
NCBIRefSeq:N/A
Image(s):N/A
ShippingMethod:Dryiceshipping
References:1.HershkoA,etal.(1980)ProcNatlAcadSciUSA77(4),1783-1786.
2.PickartCM,(1997)FASEB11(13),1055-1066.3.HershkoA,etal.(1998)AnnRevBiochem67,425-479.
4.JiangX,etal.(2012)NatureReviewsImmunology12,35-48.