Deprecated: Required parameter $cat_id follows optional parameter $type in /www/wwwroot/ebimall.com/systems/hong.php on line 2088

Deprecated: Required parameter $where follows optional parameter $tree_id in /www/wwwroot/ebimall.com/systems/hlb.php on line 3505
ubpbio/Ubiquitin (I44A)/E1900/1 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
您好,欢迎您进入188进口试剂采购网网站! 服务热线:4000-520-616
蚂蚁淘商城 | 现货促销 | 科研狗 | 生物在线

ubpbio/Ubiquitin (I44A)/E1900/1 mg
Ubiquitin(Ub)isa76aminoacidproteinwidelyexpressedinthecytoplasmicandnucleusofcells.UbisposttranslationallyconjugatedtoproteinsbytheE1,E2,E3proteinubiquitinationcascade.UbcanbeconjugatedonproteinsasmonoUborpolyUbchains.Proteinubiquitinationplaysbothproteolyticandnonproteolyticfunctions.Usually,polyubiquitinatedproteinsaretargetedtothe26Sproteasomeforproteolysis.Typicalconcentrationtosupportinvitroubiquitinationis50-100µM.

I44isoneofthekeyresiduesofthehydrophobicpatchonUbsurface.TheI44AmutantinhibitstheinteractionsofUbwithmanyUb-bindingdomains.

AdditionalInformation

Details

Ubiquitin(Ub)isa76aminoacidproteinwidelyexpressedinthecytoplasmicandnucleusofcells.UbisposttranslationallyconjugatedtoproteinsbytheE1,E2,E3proteinubiquitinationcascade.UbcanbeconjugatedonproteinsasmonoUborpolyUbchains.Proteinubiquitinationplaysbothproteolyticandnonproteolyticfunctions.Usually,polyubiquitinatedproteinsaretargetedtothe26Sproteasomeforproteolysis.Typicalconcentrationtosupportinvitroubiquitinationis50-100µM.
I44isoneofthekeyresiduesofthehydrophobicpatchonUbsurface.TheI44AmutantinhibitstheinteractionsofUbwithmanyUb-bindingdomains.
Images(Clickimagetoenlarge)

Coomassie-stainedSDS-PAGELane1:MolecularweightMarkersLane2:5µgpurifiedUbiquitin(I44A)

新闻动态
行业前沿
技术文章
最新产品
ProductName:Ubiquitin(I44A)
AlsoKnownAs:Ub(I44A)
CatalogNo.:E1900
Size:1mg
MolecularWeight:8.5kDa
Species:Human
Source:Bacterialrecombinant
Stock:20mMTris,150mMNaCl,2mMβME,10%Glycerol
Concentration:Seetubelabel
QualityAssurance:>95%bySDS-PAGE
Storage:Storeat-80°C;avoidmultiplefreeze-thawcycles
PDFDataSheet:PDFDatasheet，MSDS
NCBIRefSeq:N/A
Image(s):N/A
ShippingMethod:Dryiceshipping
References:1.HershkoA,etal.(1980)ProcNatlAcadSciUSA77(4),1783–1786.
2.PickartCM(1997)FASEB11(13),1055–1066.3.HershkoA,etal.(1998)AnnRevBiochem67,425–479.
4.JiangX,etal.(2012)NatureReviewsImmunology12,35–48.5.BremmA,etal.(2012)MethodsMolBiol832,291–228.