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ubpbio/SBI0206965/F6210/5 mg
SBI-0206965isapotentinhibitoroftheautophagykinaseULK1.ItinhibitsULK1andULK2kinaseswithIC₅₀of108nMand711nM,respectively.ULK1isaserine/threoninekinaseactingupsteamofPI3Ktoregulatetheformationofautophagophores,theprecursorsofautophagosomes,inresponsetonutrientdeprivation.SBI-0206965suppressesULK1-mediatedphosphorylationeventsincells,regulatingautophagyandcellsurvival.

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SBI-0206965isapotentinhibitoroftheautophagykinaseULK1.ItinhibitsULK1andULK2kinaseswithIC₅₀of108nMand711nM,respectively.ULK1isaserine/threoninekinaseactingupsteamofPI3Ktoregulatetheformationofautophagophores,theprecursorsofautophagosomes,inresponsetonutrientdeprivation.SBI-0206965suppressesULK1-mediatedphosphorylationeventsincells,regulatingautophagyandcellsurvival.

Solubility:
10mg/mlinDMSO

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ProductName:SBI-0206965
AlsoKnownAs:2-(5-bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yloxy)-N-methylbenzamide
CatalogNo.:F6210
Size:5mg
CAS:N/A
Formula:C21H21BrN4O5
MolecularWeight:489.32Da
Form:Lyophilizedpowder
QualityAssurance:>98%byHPLCandNMR
Source:Synthetic
Storage:Eligibleforroomtemperatureshipping.Storeat-80°Cuponreceiving
PDFDataSheet:DownloadPDFdatasheet
Image(s):N/A
ShippingMethod:Roomtemperatureshipping
References:Egan,DF,etal.(2015)MolCell59285-297.