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Xcessbio/Hh-Ag1.5, Hedgehog Agonist -Xcessbio Biosciences Inc/2 mg solid/M60004-2s188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Xcessbio/Hh-Ag1.5, Hedgehog Agonist -Xcessbio Biosciences Inc/2 mg solid/M60004-2s

Details
Product Information
Molecular Weight:526.04
Formula:C28H26ClF2N3OS
Purity:≥98%
CAS#:612542-14-0
Solubility:DMSO up to 50 mM
Chemical Name:3-chloro-4,7-difluoro-N-(4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide
Storage:Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year.

Biological Activity:

Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50~1 nM. Studies showed that it has more potent activity than the recombinant Hh protein in activating Smo and hedgehog pathway.

How to Use:

  • In vitro:Hh-Ag1.5 was used at 25 nM to induce Hh pathway activation in the reporter gene assay. It was suggested to use at 0.1 µM to replace recombinant Hh protein.
  • In vivo:n/a

Reference:

  • 1. Frank-Kamenetsky M, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. (2002) Journal of Biology (1): 10.2-10.19.
  • 2. Borzillo GV, et al. The Hedgehog Signaling Pathway as a Target for Anticancer Drug Discovery. (2005) Current Topics in Medicinal Chemistry (5), 147-157.
  • 3. Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med. Chem. Lett., 2010, 1 (3), pp 130–134.

  • Hh-Ag1.5_spec.pdf
  • Hh_Ag1.5_MSDS.pdf

Products are for research use only. Not for human use.

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