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Xcessbio/ML141, Cdc42 GTPase Inhibitor-Xcessbio Biosciences Inc/10 mM in DMSO (0.491 mL)/M60134-2188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Xcessbio/ML141, Cdc42 GTPase Inhibitor-Xcessbio Biosciences Inc/10 mM in DMSO (0.491 mL)/M60134-2

Details
Product Information
Molecular Weight:407.49
Formula:C22H21N4O3S
Purity:≥98%
CAS#:71203-35-5
Solubility:DMSO up to 100 mM
Chemical Name:4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
Storage:Powder:4oC 1 year. DMSO:4oC3 month;-20oC 1 year.

Biological Activity:

ML141 is a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase. The EC50for Cdc42 wild type and Cdc42Q61L mutant were 2.1 and 2.6 μM respectively. It has excellent selectivity for Cdc42 with no inhibition toward Rho and Rac in the same GTPase family, including Rac1, Rab2 and Rab7. In cellular assays ML141 inhibited Cdc42-related filopodia formation and cell migration.

How to Use:

  • In vitro:ML141 was used at 10 µM final concentration in various in vitro assays.
  • In vivo:not reported

Reference:

  • 1. Chen HY, et al. Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells. (2013) EMBO Mol Med. 5(5):723-36.
  • 2. Surviladze Z, et al. A Potent and Selective Inhibitor of Cdc42 GTPase. (2010) Probe Reports from the NIH Molecular Libraries Program.
  • ML141_spec.pdf
  • ML141_MSDS.pdf

Products are for research use only. Not for human use.

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