MTA1 Peptide middle region (AAP35738)

货号：	AAP35738
英文名：	MTA1
保存条件：	Add100ulofsterilePBS.Finalpeptideconcentrationis1mg/mlinPBS.Forlongerperiodsofstorage,storeat-20C.Avoidrepeatfreeze-thawcycles.
规格：	100ug

NCBIGeneId:9112
SwissprotId:Q13330-2
Thisgeneencodesaproteinthatwasidentifiedinascreenforgenesexpressedinmetastaticcells,specifically,mammaryadenocarcinomacelllines.Expressionofthisgenehasbeencorrelatedwiththemetastaticpotentialofatleasttwotypesofcarcinomasalthoughitisalsoexpressedinmanynormaltissues.Theroleitplaysinmetastasisisunclear.Itwasinitiallythoughttobethe70kDcomponentofanucleosomeremodelingdeacetylasecomplex,NuRD,butitismorelikelythatthiscomponentisadifferentbutverysimilarprotein.Thesetwoproteinsaresocloselyrelated,though,thattheysharethesametypesofdomains.ThesedomainsincludetwoDNAbindingdomains,adimerizationdomain,andadomaincommonlyfoundinproteinsthatmethylateDNA.Theprofileandactivityofthisgeneproductsuggestthatitisinvolvedinregulatingtranscriptionandthatthismaybeaccomplishedbychromatinremodeling.Twotranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.-Seemoreat:http://www.avivasySBIo.com/sd/tds/html_datasheet.php?sku=AAP00000