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avivasysbio/Anti-GABA Transporter (GAT) 1 (OAPC00137)/OAPC00137/100 ul

Gene Symbol:
SLC6A1
NCBI Gene Id:
79212
Protein Name:
Sodium- and chloride-dependent GABA transporter 1
Swissprot Id:
P23978
Protein Accession #:
NP_077347.1
Description of Target:
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).
Molecular Weight:
~67kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Prepared from rabbit serum by affinity purification.
Application:
WB, IHC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SLC6A1.
RNA Seq:
Find tissues and cell lines supported by DNA array analysis to express SLC6A1.
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat GAT-1.
Predicted Species Reactivity:
Mouse, Rat
Predicted Homology Based on Immunogen Sequence:
Mouse; Rat
Product Format:
Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
Reconstitution and Storage:
For long term storage -20C is recommended. Stable at -20C for at least 1 year.
Datasheets/Manuals:
Printable datasheet for OAPC00137
Specificity:
Specific for the ~67k GAT-1 protein. Immunolabeling is blocked by the peptide used as antigen.
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