ITCH Antibody Nterminal (OAPB01848)

货号：	OAPB01848
抗体英文名：	ITCHAntibody-N-terminal(OAPB01848)
靶点：	ITCH
应用范围：	ELISA,WB
宿主：	Rabbit
适应物种：	Human,Mouse,Rat
克隆性：	否
保存条件：	Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.
形态：	Liquid,1mg/mLprovidedinPBScontaining0.02%sodiumazide.
亚型：	IgG
免疫原：	ITCHantibodywasraisedagainsta15aminoacidpeptideneartheaminoterminusofhumanITCH
规格：	100ug

NCBIGeneId:83737
SwissprotId:Q96J02
TheItchyE3ubiquitinproteinligase(ITCH)isamemberoftheNedd4familyofHECTdomainE3ubiquitinligases(1).HECTdomainE3ubiquitinligasestransferubiquitinfromE2ubiquitin-conjugatingenzymestoproteinsubstrates,thustargetingspecificproteinsforlysosomaldegradation.ITCHplaysaroleinmultiplecellularprocessesincludingerythroidandlymphoidcelldifferentiationandtheregulationofimmuneresponses(2).InBcells,ITCHisthoughttoassociatewithlatentmembraneprotein2A(LMP2A)ofEpstein-Barrvirus,specificallydown-regulatingitsactivityinBcellsignaling(3).Mutationsinthisgeneareacauseofsyndromicmultisystemautoimmunedisease(4).-Seemoreat:http://www.avivasySBIo.com/sd/tds/html_datasheet.php?sku=OAPB01848

3T3celllysate

WesternblotanalysisofITCHin3T3celllysatewithITCHantibodyat1ug/mlin(A)theabsenceand(B)thepresenceofblockingpeptide.