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avivasysbio/AMACR Antibody (OASL00277)/100ul/OASL00277

Predicted Species Reactivity:
Human
Product Format:
Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
IHC
Additional Information:
Background: AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4).
:::
Location: Cytoplasm
:::
Positive Tissue: ovary cancer, bladder cancer, prostate cancer
Reconstitution and Storage:
Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Immunogen:
KLH conjugated Synthetic peptide corresponding to Human AMACR
Purification:
Affinity purification
Datasheets/Manuals:
Printable datasheet for OASL00277
Application Info:
IHC: 1:1000 - 1:2000
Gene Symbol:
AMACR
Alias Symbols:
2-methylacyl-CoA racemase, AMACR
Protein Name:
Alpha-methylacyl-CoA racemase
Swissprot Id:
Q9UHK6
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