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TGFBR2 Recombinant Protein (OPCD07394)
货号：OPCD07394
英文名：TGFBR2
保存条件：ReconstituteinPBSorothers.
Storeat2-8Cforonemonth.Aliquotandstoreat-80Cfor12months.Avoidrepeatedfreeze/thawcycles.
规格：10ug
NCBIGeneId:21813
SwissprotId:Q62312
Transmembraneserine/threoninekinaseformingwiththeTGF-betatypeIserine/threoninekinasereceptor,TGFBR1,thenon-promiscuousreceptorfortheTGF-betacytokinesTGFB1,TGFB2andTGFB3.TransducestheTGFB1,TGFB2andTGFB3signalfromthecellsurfacetothecytoplasmandisthusregulatingaplethoraofphysiologicalandpathologicalprocessesincludingcellcyclearrestinepithelialandhematopoieticcells,controlofmesenchymalcellproliferationanddifferentiation,woundhealing,extracellularmatrixproduction,immunosuppressionandcarcinogenesis.Theformationofthereceptorcomplexcomposedof2TGFBR1and2TGFBR2moleculessymmetricallyboundtothecytokinedimerresultsinthephosphorylationandtheactivationofTGFRB1bytheconstitutivelyactiveTGFBR2.ActivatedTGFBR1phosphorylatesSMAD2whichdissociatesfromthereceptorandinteractswithSMAD4.TheSMAD2-SMAD4complexissubsequentlytranslocatedtothenucleuswhereitmodulatesthetranscriptionoftheTGF-beta-regulatedgenes.ThisconstitutesthecanonicalSMAD-dependentTGF-betasignalingcascade.Alsoinvolvedinnon-canonical,SMAD-independentTGF-betasignalingpathways.-Seemoreat:http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OPCD07394

TGFBR2 Recombinant Protein (OPCD07394) using SDS-PAGE

SDS-PAGE

TGFBR2RecombinantProtein(OPCD07394)usingSDS-PAGE

温馨提示：不可用于临床治疗。

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