C3 Recombinant Protein (OPCD01758)

货号：	OPCD01758
英文名：	C3
保存条件：	Reconstitutein20mMTris,150mMNaCl(pH8.0)toaconcentrationof0.1-1.0mg/mL.Donotvortex. Storeat2-8Cforonemonth.Aliquotandstoreat-80Cfor12months.Avoidrepeatedfreeze/thawcycles.
规格：	10ug

NCBIGeneId:12266
SwissprotId:P01027
C3playsacentralroleintheactivationofthecomplementsystem.ItsprocessingbyC3convertaseisthecentralreactioninbothclassicalandalternativecomplementpathways.AfteractivationC3bcanbindcovalently,viaitsreactivethioester,tocellsurfacecarbohydratesorimmuneaggregates.DerivedfromproteolyticdegradationofcomplementC3,C3aanaphylatoxinisamediatoroflocalinflammatoryprocess.Inchronicinflammation,actsasachemoattractantforneutrophils.Itinducesthecontractionofsmoothmuscle,increasesvascularpermeabilityandcauseshistaminereleasefrommastcellsandbasophilicleukocytes.TheshortisoformhasB-cellstimulatoryactivity.C3-beta-c:Actsasachemoattractantforneutrophilsinchronicinflammation.Acylationstimulatingprotein:adipogenichormonethatstimulatestriglyceride(TG)synthesisandglucosetransportinadipocytes,regulatingfatstorageandplayingaroleinpostprandialTGclearance.AppearstostimulateTGsynthesisviaactivationofthePLC,MAPKandAKTsignalingpathways.LigandforC5AR2.Promotesthephosphorylation,ARRB2-mediatedinternalizationandrecyclingofC5AR2.-Seemoreat:http://www.avivasysbio.com/sd/tds/html_datasheet.php?sku=OPCD01758

SDS-PAGE

C3RecombinantProtein(OPCD01758)usingSDS-PAGE