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Sino Biological/Neurofascin Protein, Human, Recombinant (His Tag)/1/15694-H08H

Description
Related Products
Citations
Protein Expression Service

Neurofascin Protein, Human, Recombinant (His Tag): Product Information

Purity

> 95 % as determined by SDS-PAGE

Endotoxin

< 1.0="" eu="" per="" μg="" of="" the="" protein="" as="" determined="" by="" the="" lal="">

Activity

Testing in progress

Protein Construction

A DNA sequence encoding the human NFASC (O94856-12) (Met1-Gln939) was expressed with a C-terminal polyhistidine tag.

Accession#

O94856-12

Expressed Host

HEK293 Cells

Species

Human

Predicted N Terminal

Ile 25

Molecule Mass

The recombinant human NFASC comprises 926 amino acids and has a predicted molecular mass of 104.4 kDa. The apparent molecular mass of the protein is approximately 114-119 kDa in SDS-PAGE under reducing conditions.

Formulation

Lyophilized from sterile PBS, pH 7.4.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.

Please refer to the specific buffer information in the hard copy of CoA.

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Stability & Storage

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Reconstitution

A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Neurofascin Protein, Human, Recombinant (His Tag): Images

Neurofascin Protein, Human, Recombinant (His Tag): Synonyms

NF Protein, Human; NRCAML Protein, Human

Neurofascin Background Information

NFASC (Neurofascin, also known as NRCAML, NEDCPMD, and NF) is a Protein Coding gene. 13 alternatively spliced human isoforms have been reported. NFASC belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton. It is broadly expressed in the brain, kidney, and other tissues. Diseases associated with NFASC include Neurodevelopmental Disorder With Central And Peripheral Motor Dysfunction and Demyelinating Polyneuropathy.

Full Name

neurofascin

References

Volkmer H. et al., 1992, J Cell Biol. 118 (1): 149-61.
Burmeister M. et al., 1996, Mamm Genome. 7 (7): 558-9.
Ango F. et al., 2004, Cell. 119 (2): 257-72.

Human Neurofascin Proteins

Neurofascin Protein, Human, Recombinant (hFc Tag), Biotinylated15694-H02H-B
Neurofascin Protein, Human, Recombinant (hFc Tag)15694-H02H

Anti-pan-neurofascin IgG3 as a marker of fulminant autoimmune neuropathy
Author
Stengel, H;Vural, A;Brunder, AM;Heinius, A;Appeltshauser, L;Fiebig, B;Giese, F;Dresel, C;Papagianni, A;Birklein, F;Weis, J;Huchtemann, T;Schmidt, C;Körtvelyessy, P;Villmann, C;Meinl, E;Sommer, C;Leypoldt, F;Doppler, K;
Year
2019
Journal
Neurol Neuroimmunol Neuroinflamm
Application
ELISA
PubMed ID: 31454780FoldedExpand

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Sino Biological/Neurofascin Protein, Human, Recombinant (His Tag)/1/15694-H08H

Description

Related Products

Citations

Protein Expression Service

Neurofascin Protein, Human, Recombinant (His Tag): Product Information

Neurofascin Protein, Human, Recombinant (His Tag): Images

Neurofascin Protein, Human, Recombinant (His Tag): Synonyms

Neurofascin Background Information

Human Neurofascin Proteins

Citation List

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