| Product name | Human Fetuin-A![]() | ||||||
| Cat-Nr. | KT-800 | ||||||
| Range | 12.5 - 370 ng/ml | ||||||
| Sensitivity | 5.0 ng/ml | ||||||
| Incubation time | 3 hours | ||||||
| Sample volume | 10 µl (dilute 1:10.000) | ||||||
| Sample type | Serum | ||||||
| Sample preparation | Serum should be separated within 3 hours after blood collection, measure or store at -20°C. Max. 3 freeze and thaw cycles. | ||||||
| Reference values |
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| Species | Human | ||||||
| Tests | 96 | ||||||
| Method | ELISA | ||||||
| Intended use | Fetuin-A synthesized in the liver is secreted into the blood stream and it is deposited, accumulated as a noncollagenous protein in mineralized bones and teeth. Fetuin-A acts as an important circulating inhibitor of ectopic calcification, a frequently seen complication in degenerative diseases. Low Fetuin-A level may be associated with higher cardiovascular mortality in chronic renal failure, liver cancer and liver cirrhosis patients on long-term dialysis. Human Fetuin-A represents a natural inhibitor of tyrosine kinase activity of the insulin receptor. Fetuin-A may play a significant role in regulating post-prandial glucose disposition, insulin sensitivity, weight gain, and fat accumulation and may be a novel therapeutic target in the treatment of type 2 diabetes, obesity, and other insulin-resistant conditions. • Fetuin-A level (< 0.35 g/l) indicates a higher risk of cardiovascular calcification and increase mortality in ESRD-patients. • Fetuin-A level (> 1.00 g/l) in elderly population, an independent risk factor of type II diabetes. • Fetuin-A is an important predictor of death in acute myocardial infarction. • Involved with the regulation of calcium metabolism and osteogenesis. | ||||||
| Product informations | Kit Instructions (PDF 185,7 kB) Cross-reaction all species (PDF 74,6 kB) Bone & Cartilage Metabolism (PDF 1,8 MB) Metabolisches Syndrom (Diabetes) Monograph (PDF 2,0 MB) |
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