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Cellagentech/VX-680 (Tozasertib) | Aurora A inhibitor/C8916-10/10 mg (powder)188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Cellagentech/VX-680 (Tozasertib) | Aurora A inhibitor/C8916-10/10 mg (powder)

ProductDescription

VX-680(Tozasertib)isasmallmoleculeAurorakinaseinhibitor(Aurora-A~0.6nM,Aurora-B~18nM,Aurora-C~4.6nM).VX-680inhibitscellcycleprogression,inducesapoptosisandblockstumorgrowthinvarietiesofinvivoxenograftmodels,includingleukemia,colonandpancreatictumors.

Technicalinformation:

ChemicalFormula: C23H28N8OS
CAS#: 639089-54-6
MolecularWeight: 464.59
Purity: >98%
Appearance: Lightyellowsolid
ChemicalName: N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)thio)phenyl)cyclopropanecarboxamide
Solubility: Upto100mMinDMSO

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storage:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.

Reference:

1.ElizabethAHarrington,etal.VX-680,apotentandselectivesmall-moleculeinhibitoroftheAurorakinases,suppressestumorgrowthinvivo.NatureMedicine2004;10,262–267.
2.MarumotoT,ZhangD,SayaH.Aurora-A-aguardianofpoles.NatRevCancer.2005;5(1):42-50.

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