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Cellagentech/RO4929097 | γ-secretase inhibitor/C7649-2s/2 mg (10 mM solution in DMSO)188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Cellagentech/RO4929097 | γ-secretase inhibitor/C7649-2s/2 mg (10 mM solution in DMSO)

ProductDescription

RO4929097isapotentandselectivesmallmoleculeinhibitorofγ-secretase(IC50=4nM),producinginhibitoryactivityofNotchsignalingintumorcells.ItinhibitsNotchprocessingintumorcellsasmeasuredbythereductionofintracellularNotchexpressionbyWesternblot.ThisleadstoreducedexpressionoftheNotchtranscriptionaltargetgeneHes1.RO4929097doesnotblocktumorcellproliferationorinduceapoptosisbutinsteadproducesalesstransformed,flattened,slower-growingphenotype.CurrentitisinphaseIstudyinpatientswithadvancedsolidtumors.

ProductCitation

NOTE:UnderlicensingagreementwithHoffmann-LaRocheLtd,thisproductistobeusedforinvitrostudyonly.

Technicalinformation:

ChemicalFormula: C22H20F5N3O3
CAS#: 847925-91-1
MolecularWeight: 469.40
Purity: >98%
Appearance: Whitesolid
ChemicalName: 2,2-dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide
Solubility: Upto50mMinDMSO

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storage:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.

Reference:

1.LuistroL,HeWetal.Preclinicalprofileofapotentgamma-secretaseinhibitortargetingnotchsignalingwithinvivoefficacyandpharmacodynamicproperties.CancerRes.2009;69(19):7672-80.

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