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Cellagentech/Trichostatin A (TSA) | HDAC inhibitor/C8742-2s/2 mg (10 mM solution in DMSO)

ProductDescription

TrichostatinA(TSA)isapotenthistonedeacetylase(HDAC)inhibitor.ItinhibitsHDAC1,2,3,6,10,11atIC50soflessthan10nM,withover300-foldselectivityagainstclassIIaHDACs.[1]TSAaffectsDNAreplicationandgeneexpressionbyinhibitingHDACactivityandthereforealteringthehistonemodificationsandaccessofDNAinsidechromatin.

TrichostatinAinducesapoptosisandcellgrowtharrestatbothGandG/Mphases.AsHDACsareoverexpressedinmanycancertypes,TSAiswidelyusedtoprobethetumOrigenesismechanismtargetingHDAC.[2]TrichostatinAwasfoundtopreventthedifferentiationofembryonicstemcell,[3]whileTSAtreatmentincreasedfunctionalcharacteristicsofhumanESC/iPSC-derivedcardiomyocytes.[4]

Technicalinformation:

ChemicalFormula: C17H22N2O3
CAS#: 58880-19-6
MolecularWeight: 302.37
Purity: >98%
Appearance: Brown
ChemicalName: (R,2E,4E)-6-(4-(dimethylamino)benzoyl)-N-hydroxy-4-methylhepta-2,4-dienamide
Solubility: Upto50mMinDMSO
Synonyms: TrichostatinA,TSA

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderorDMSOsolutionat-20oCdesiccated.

Reference:

1.LoberaM,etal.SelectiveclassIIahistonedeacetylaseinhibitionviaanonchelatingzinc-bindinggroup.NatChemBiol.2013;9(5):319-25.PubmedID:23524983
2.TimmermannS,etal.Histoneacetylationanddisease.CellMolLifeSci.2001;58(5-6):728-36.ReviewPubmedID:11437234
3.LeeJH,etal.Histonedeacetylaseactivityisrequiredforembryonicstemcelldifferentiation.Genesis.2004;38(1):32-8.PubmedID:14755802
4.OtsujiTG,etal.DynamiclinkbetweenhistoneH3acetylationandanincreaseinthefunctionalcharacteristicsofhumanESC/iPSC-derivedcardiomyocytes.PLoSOne.2012;7(9):e45010PubmedID:11437234

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