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Cellagentech/Prucalopride | 5-HT4 receptor agonist/C7782-5/5 mg (powder)188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Cellagentech/Prucalopride | 5-HT4 receptor agonist/C7782-5/5 mg (powder)

ProductDescription

Prucaloprideisanorally-available,dibenzofuran-based,enterokineticagoNISTofthehumanSEROtonin5-HT4aand5-HT4breceptorisoformswithKiestimatesof3nMand8nM,respectively.IthasmodestselectivityoverthehumanD4receptor(2.3uM),mouse5-HT3receptor(3.7uM)andhumans1receptor(3.7uM).(1,2)

InitialtolerABIlitystudiesshowthatprucalopridedoesnotencountercardiotoxicityissuestotheextentseeninotherdrugsofthisclass.[3]

Technicalinformation:

ChemicalFormula: C18H26ClN3O3
CAS#: 179474-81-8
MolecularWeight: 367.87
Purity: >98%
Appearance: White
ChemicalName: 7-Benzofurancarboxamide,4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]
Solubility: Upto100mMinDMSO
Synonyms: 0

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.

Reference:

1.Briejeretal.,Theinvitropharmacologicalprofileofprucalopride,anovelenterokineticcompound,Eur.J.Pharmcol.2001,423,71-83.PubmedID:11438309
2.Framptonetal.,Prucalopride:ADISDrugProfile.Drugs,2009,69(17),2453-2476.PubmedID:19911858
3.Quigleyetal.,Prucalopride:safety,efficacyandpotentialapplications.Ther.Adv.Gastroenterol.2012,5(1),23-30.

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