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Cellagentech/Cyclophosphamide | DNA alkylating agent/C2936-10/10 mg (powder)188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Cellagentech/Cyclophosphamide | DNA alkylating agent/C2936-10/10 mg (powder)

ProductDescription

Cyclophosphamide,animmunosuppressantadmiNISTeredeitherorallyorintravenously,isanantineoplasticprodrugmetabolizedbyP450enzymestophosphoramidemustardandacroleinwhichinturnalkylateDNAandproteins,respectively[1].Itiswidelyusedinthetreatmentofchroniclymphocyticleukemia,lymphomas,andsofttissueandosteogenicsarcomas.[2]

Cyclophosphamidewasshowntoinduceapoptosisinwt9LgliosarcomacellsthatdidnotexpressBcl-2.Bcl-2diminishescyclophosphamide"scytotoxicactivity,butnotcytostaticactivity.[1]

Technicalinformation:

ChemicalFormula: C7H15Cl2N2O2P.H2O
CAS#: 6055-19-2
MolecularWeight: 261.09
Purity: >99%
Appearance: WhiteCrystalline
ChemicalName: (RS)-N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine2-oxide
Solubility: Upto100mMinDMSO
Synonyms: Cyclophosphamide,Endoxan,Cytoxan,Neosar,Procytox,Revimmune,Cytophosphane

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.

Reference:

1.Schwartzetal.,Cyclophosphamideinducescaspase9-dependentapoptosisin9Ltumorcells.Mol.Pharmcol.2001,60(6),1268-1279.PubmedID:11723234
2.CyclophosphamideIARCmonograph

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