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| Description | |
|---|---|
| CatalogueNumber | AB9634 |
| Replaces | 04-1066 |
| BrandFamily | Chemicon® |
| TradeName |
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| Description | Anti-PostSynapticDensity95Antibody |
| AlternateNames |
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| ProductInformation | |
|---|---|
| Format | AffinityPurified |
| Presentation | Affinitypurifiedimmunoglobulin.Liquidin10mMHEPES(pH7.5),150mMNaCl,100μg/mLBSAand50%glycerol. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedforupto6monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles.Donotstoreinaselfdefrostingfreezer. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | SyntheticpeptidefromtheN-terminalofratPSD-95. |
| Host | Rabbit |
| Specificity | Postsynapticdensity95(PSD-95).Theantibodyrecognizesaproteinof~95kDacorrespondingtoPSD-95inlysatesfromratbrainhippocampus.Anadditionalbandof~44kDamayalsobeseendependingonsampleandantibodyconcentrationused. |
| Isotype | IgG |
| SpeciesReactivity |
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| SpeciesReactivityNote | Theimmunogenhas100%similaritywithhumanandmouse. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesamemberofthemembrane-associatedguanylatekinase(MAGUK)family.ItheteromultimerizeswithDLG2.WithDLG2itisrecruitedintothesameNMDAreceptorandpotassiumchannelclusters.ThesetwoMAGUKproteinsmayinteractatpostsynapticsitestoformamultimericscaffoldfortheclusteringofreceptors,ionchannels,andassociatedsignalingproteins. |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P78352#InteractswiththecytoplasmictailofNMDAreceptorsubunitsandshaker-typepotassiumchannels.RequiredforsynapticplasticityassociatedwithNMDAreceptorsignaling.OverexpressionordepletionofDLG4changestheratioofexcitatorytoinhibitorysynapsesinhippocampalneurons.MayreducetheamplitudeofACCN3acid-evokedcurrentsbyretainingthechannelintracellularly.MayregulatetheintracellulartraffickingofADR1B(Bysimilarity). SIZE:724aminoacids;80495Da SUBUNIT:InteractsthroughitsfirsttwoPDZdomainswithGRIN2A,GRIN2B,GRIN2C,GRIN2D,ACCN3,certainspliceformsofGRIN1,KCND2,CXADRandSYNGAP1.InteractsthroughitssecondPDZdomainwiththePDZdomainofNOS1ortheC-terminusofCAPON.MayinteractwithHTR2A.Interactsthroughitsguanylatekinase-likedomainwithDLGAP1/GKAP,DLGAP2,DLGAP3,DLGAP4,MAP1A,andBEGAIN(Bysimilarity).InteractsthroughitsfirsttwoPDZdomainswithKCNA1,KCNA2,KCNA3,KCNA4andERBB4.InteractsthroughitsfirstPDZdomainwithGRIK2,KCNA4andCRIPT.InteractsthroughitsthirdPDZdomainwithNLGN1,andprobablywithNLGN2andNLGN3.Interactsthroughitsguanylatekinase-likedomainwithKIF13B.Isoform2interactsthroughanL27domainwithHGS/HRSandthefirstL27domainofCASK. SUBCELLULARLOCATION:Cellmembrane;Peripheralmembraneprotein.Celljunction,synapse,postsynapticcellmembrane,postsynapticdensity.Celljunction,synapse.Note=Highlevelsinpostsynapticdensityofneuronsintheforebrain.AlsoinpresynapticregionofinhibitorysynapsesformedbycerebellarbasketcellsonaxonhillocksofPurkinjecells. TISSUESPECIFICITY:Brain. DOMAIN:SwissProt:P78352ThePDZdomain3mediatesinteractionwithADR1B.&TheL27domainneartheN-terminusofisoform2isrequiredforHGS/HRS-dependenttargetingtopost-synapticdensity. PTM:Palmitoylationofisoform1isrequiredfortargetingtopostsynapticdensity(Bysimilarity). SIMILARITY:BelongstotheMAGUKfamily.&Contains1guanylatekinase-likedomain.&Contains3PDZ(DHR)domains.&Contains1SH3domain. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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