Description | |
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CatalogueNumber | AB3830 |
BrandFamily | Chemicon® |
TradeName |
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Description | Anti-Caveolin-1Antibody,phospho-specific(Tyr14) |
ProductInformation | |
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Format | AffinityPurified |
Presentation | ProteinAandpeptideaffinitypurifiedimmunoglobulin.Liquidin10mMsodiumHEPES,pH7.5,150mMNaCl,100μg/mlBSA,with50%glycerol. |
StorageandShippingInformation | |
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StorageConditions | Maintainat-20ºCfor12months,donotaliquot. |
BIOLOGicalInformation | |
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Immunogen | KLH-conjugated,syntheticphospho-peptidecorrespondingtoresiduessurroundingTyr14ofhumancaveolin-1 |
Epitope | phospho-specific(Tyr14) |
Host | Rabbit |
Specificity | Recognizescaveolin-1onlywhenphosphorylatedattyrosine14.Thisantibodydoesnotcross-reactwithcaveolin-2,-3orcaveolin-1beta,ortheshortisoformofcaveolin-1. |
SpeciesReactivity |
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AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thescaffoldingproteinencodedbythisgeneisthemaincomponentofthecaveolaeplasmamembranesfoundinmostcelltypes.TheproteinlinksintegrinsubunitstothetyrosinekinaseFYN,aninitiatingstepincouplingintegrinstotheRas-ERKpathwayandpromotingcellcycleprogression.ThegeneisatumorsuppressorgenecandidateandanegativeregulatoroftheRas-p42/44MAPkinasecascade.CAV1andCAV2arelocatednexttoeachotheronchromosome7andexpresscolocalizingproteinsthatformastablehetero-oligomericcomplex.ByusingalternativeinitiationcodonsinthesamereADIngframe,twoisoforms(alphaandbeta)areencodedbyasingletranscriptfromthisgene. |
GeneSymbol |
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Modifications |
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UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:Q03135#Mayactasascaffoldingproteinwithincaveolarmembranes.InteractsdirectlywithG-proteinalphasubunitsandcanfunctionallyregulatetheiractivity(Bysimilarity). SIZE:178aminoacids;20472Da SUBUNIT:Homooligomer.InteractswithGLIPR2,NOSTRIN,SNAP25andsyntaxin. SUBCELLULARLOCATION:Golgiapparatusmembrane;Peripheralmembraneprotein;Cytoplasmicside.Cellmembrane,caveola;Peripheralmembraneprotein;Cytoplasmicside.Note=Membraneproteinofcaveolae.Potentialhairpin-likestructureinthemembrane. TISSUESPECIFICITY:Inmuscleandlung,lesssoinliver,brainandkidney. PTM:TheinitiatormethionineforisoformBetaisremovedduringorjustaftertranslation.ThenewN-terminalaminoacidisthenN-acetylated. SIMILARITY:SwissProt:Q03135##Belongstothecaveolinfamily. |
PhysicochemicalInformation |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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