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| Description | |
|---|---|
| CatalogueNumber | 14-306 |
| BrandFamily | Upstate |
| TradeName |
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| Description | GSK3βProtein,active,10µg |
| Overview | N-terminalHis6-taggedrecombinanthumanGSK3βwithanH350Lmutation |
| ProductInformation |
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| StorageandShippingInformation | |
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| StorageConditions | 6monthsat-70°C |
| Applications | |
|---|---|
| Application | Active,N-terminalHis6-taggedrecombinanthumanGSK3βwithanH350Lmutation,foruseinKinaseAssays. |
| KeyApplications |
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| BIOLOGicalInformation | |
|---|---|
| Source | ExpressedbybaculovirusinSf21insectcells |
| SpecificActivity | ForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme. |
| EntrezGeneNumber | |
| EntrezGeneSummary | Glycogensynthasekinase-3(GSK3)isaproline-directedserine-threoninekinasethatwasinitiallyidentifiedasaphosphorylatingandinactivatingglycogensynthase.Twoisoforms,alpha(GSK3A;MIM606784)andbeta,showahighdegreeofaminoacidhomology(StambolicandWoodgett,1994[PubMed7980435]).GSK3Bisinvolvedinenergymetabolism,neuronalcelldevelopment,andbodypatternformation(Plyteetal.,1992[PubMed1333807]).[suppliedbyOMIM] |
| GeneSymbol |
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| ProteinTarget | GSK3β |
| PurificationMethod | Ni2+/NTA-agarose |
| TargetSub-Family | CMGC |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P49841#ParticipatesintheWntsignalingpathway.Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN.PhosphorylatesJUNatsitesproximaltoitsDNA-bindingdomain,therebyreducingitsaffinityforDNA. SIZE:420aminoacids;46744Da SUBUNIT:Monomer(Bysimilarity).InteractswithNINandCABYR. TISSUESPECIFICITY:Expressedintestis,thymus,prostateandovaryandweaklyexpressedinlung,brainandkidney. PTM:PhosphorylatedbyAKT1andILK1. SIMILARITY:SwissProt:P49841##Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily.&Contains1proteinkinasedomain. |
| MolecularWeight | 51kDa |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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