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Millipore/14-306 | GSK3β Protein, active, 10 µg/14-306/10 µgAlso available in 250μg size (2x125μg)--call for prici188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Millipore/14-306 | GSK3β Protein, active, 10 µg/14-306/10 µgAlso available in 250μg size (2x125μg)--call for prici

Description
CatalogueNumber14-306
BrandFamilyUpstate
TradeName
  • Upstate
DescriptionGSK3βProtein,active,10µg
OverviewN-terminalHis6-taggedrecombinanthumanGSK3βwithanH350Lmutation
ProductInformation
StorageandShippingInformation
StorageConditions6monthsat-70°C
Applications
ApplicationActive,N-terminalHis6-taggedrecombinanthumanGSK3βwithanH350Lmutation,foruseinKinaseAssays.
KeyApplications
  • KinaseAssay
BIOLOGicalInformation
SourceExpressedbybaculovirusinSf21insectcells
SpecificActivityForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme.
EntrezGeneNumber
EntrezGeneSummaryGlycogensynthasekinase-3(GSK3)isaproline-directedserine-threoninekinasethatwasinitiallyidentifiedasaphosphorylatingandinactivatingglycogensynthase.Twoisoforms,alpha(GSK3A;MIM606784)andbeta,showahighdegreeofaminoacidhomology(StambolicandWoodgett,1994[PubMed7980435]).GSK3Bisinvolvedinenergymetabolism,neuronalcelldevelopment,andbodypatternformation(Plyteetal.,1992[PubMed1333807]).[suppliedbyOMIM]
GeneSymbol
  • GSK3B
ProteinTargetGSK3β
PurificationMethodNi2+/NTA-agarose
TargetSub-FamilyCMGC
UniProtNumber
UniProtSummaryFUNCTION:SwissProt:P49841#ParticipatesintheWntsignalingpathway.Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN.PhosphorylatesJUNatsitesproximaltoitsDNA-bindingdomain,therebyreducingitsaffinityforDNA.
SIZE:420aminoacids;46744Da
SUBUNIT:Monomer(Bysimilarity).InteractswithNINandCABYR.
TISSUESPECIFICITY:Expressedintestis,thymus,prostateandovaryandweaklyexpressedinlung,brainandkidney.
PTM:PhosphorylatedbyAKT1andILK1.
SIMILARITY:SwissProt:P49841##Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily.&Contains1proteinkinasedomain.
MolecularWeight51kDa
PhysicochemicalInformation
Dimensions
MaterialsInformation
MaterialsInformation
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